Upper digestive tract

Stomach cancer

Stomach cancer is quiet in its early stages, which is exactly why the early signs matter. Caught early it is far more treatable, and a gastroscopy is how it is caught.

Also known as: Gastric cancer · Cancer of the stomach

Stomach cancer

Understanding stomach cancer

Why it hides early

Early stomach cancer produces symptoms that are indistinguishable from ordinary indigestion: mild discomfort, bloating, a little nausea, a bit less appetite. Nothing about them says anything is seriously wrong.

By the time the more obvious symptoms appear, such as weight loss, vomiting or difficulty swallowing, the disease is usually more advanced. This is the entire argument for taking persistent new indigestion seriously in older adults rather than treating it indefinitely.

Understanding stomach cancer

Risk factors

Several factors raise risk, and the most important one is treatable:

  • Long-standing H. pylori infection, the single most important modifiable risk factor
  • Chronic gastritis and changes in the stomach lining over many years
  • A diet heavy in salted, smoked or preserved foods and low in fresh fruit and vegetables
  • Smoking, and heavy alcohol use
  • Being over 50, and being male
  • A family history of stomach cancer
  • Previous stomach surgery, or pernicious anaemia

Understanding stomach cancer

Symptoms to know

The pattern that should prompt an endoscopy is new, persistent upper abdominal symptoms in someone over 45, or symptoms at any age accompanied by an alarm feature.

Watch particularly for indigestion that does not respond as expected to treatment, early fullness after small meals, a gradual loss of appetite, unintended weight loss, difficulty swallowing, or an unexplained low blood count that suggests slow bleeding.

Understanding stomach cancer

How it is diagnosed

Gastroscopy is the definitive test. It lets us see the stomach lining directly and take biopsies from anything abnormal, which is what establishes the diagnosis.

Where cancer is confirmed, staging scans determine how far it has spread, and the case is discussed with surgeons and oncologists to plan treatment. Being inside a teaching hospital matters here, because that whole team is on the same campus.

Understanding stomach cancer

Treatment and outlook

Treatment depends on the stage. Very early cancers confined to the lining can sometimes be removed endoscopically. More established disease is treated with surgery, often combined with chemotherapy, and sometimes radiotherapy.

The single greatest determinant of outcome is stage at diagnosis. Early-stage stomach cancer has a substantially better outlook than advanced disease, which is why we scope people over 45 with new persistent symptoms rather than treating blindly.

Understanding stomach cancer

Reducing your risk

Not all risk is modifiable, but a meaningful part of it is:

  • Get tested and treated for H. pylori if you have ulcer-type symptoms or a family history
  • Stop smoking
  • Reduce salted, smoked and heavily preserved foods; increase fresh fruit and vegetables
  • Keep alcohol moderate
  • Do not ignore persistent new indigestion after 45

Common questions

What are the early signs of stomach cancer?

Early disease often causes only mild indigestion, bloating, early fullness or slight loss of appetite. New, persistent indigestion after 45 is the pattern most worth investigating.

Does H. pylori cause stomach cancer?

Long-standing H. pylori infection is the most important modifiable risk factor for stomach cancer, though the great majority of people who carry it never develop it. Clearing the infection reduces risk.

Who should have a gastroscopy to check?

Anyone over 45 with new persistent upper abdominal symptoms, and anyone of any age with alarm features such as weight loss, difficulty swallowing, vomiting blood or unexplained anaemia.

Related conditions

Talk to the unit

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